The megatrends that will impact healthcare over the coming five to fifteen years. These incude personalized medicine [custom tailored medicine]; prevention; much improved repair, restoration; or replacement of damaged organs or tissues; the electronic medical record and better quality and safety. This will occur because of advances in biological sciences, engineering and computer science in areas such as genomics, vaccines, stem cells, medical devices, imaging, the OR of the Future, digitizing medical information and the rise of complementary medicine as mainstream. The changes will be dramatic and some will be quite disruptive or transformational.