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Evolution of the Human Lifespan, Past, Present, and Future: Phases in the Evolution of Human Life Expectancy in Relation to the Inflammatory Load

Author: Caleb. E. Finch
Organisation: University of Southern California
Publish Date: 2012
Country: Global
Sector: Social Development
Method: Creative thinking
Theme: Living Standards
Type: Article
Language: English
Tags: Life expectancy, LE, Infection, Inflammation, Environmental deterioration, Climate changes

The huge recent increases in Life expectancy (LE) are concurrent with the improvements in hygiene, nutrition, and medicine during the nineteenth and twentieth centuries that reduced mortality from infections at all ages. A hypothesis developed with Eileen Crimmins proposes that these reductions in mortality were enabled by a reduced load of chronic inflammation and infection. The load of infection and inflammation is represented by mortality at early ages, which is dominated by infectious causes. Inflammation is closely linked to most chronic diseases of aging, including Inflammation is closely linked to most chronic diseases of aging, including atherosclerosis and cancer.
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